Dr. Ma adds, "Our results show that BB1 prevented the TNF-α increase in intestinal tight junction permeability via a toll-like receptor (TLR)-2 signal transduction pathway inhibition of NF-kB p50 ...

This study reveals the key role of microglia, brain’s immune cells, in brain metastases progression and identifies a strategy ...

Brain metastases are one of the most severe complications of melanoma, the most aggressive type of skin cancer. Researchers ...

Brain metastases are one of the most severe complications of melanoma, the most aggressive type of skin cancer. Researchers at the Institute for ...

The compound's ability to regulate various signaling pathways, such as the NF-kB pathway, further underscores its therapeutic potential in managing liver-related diseases. Moreover, HSYA is part ...

In a recent study, researchers demonstrated that Z526, a novel dithiocarbamate-like compound, mitigates cancer-associated cachexia (CAC) both in vitro and in vivo.

The adaptors activate other relay proteins inside the cell, and this chain of protein-protein interactions creates a signal transduction pathway that ... factors (such as NF-kB and IRFs) that ...

Z526- a novel dithiocarbamate-like compound reverses cancer associated cachexia via mitigating NF-B signaling and oxidative stress. In a recent ...

In cancer-associated cachexia, elevated TNF-α and IL-6 exacerbate muscle and fat loss by regulating multiple metabolic signaling pathways, which could be ameliorated by Z526's suppression of NF-κB ...

Disparate pathogenic mechanisms complicate precision-medicine efforts to treat diffuse large B-cell lymphoma (DLBCL), the most common lymphoma diagnosis. Though potentially curable with frontline ...