“We have identified a key signaling pathway, Rela/NF-kB, that, when blocked, reverses the protumoral function of microglia ...

The final targets of TLRs are DNA-binding transcription factors (such as NF-kB and IRFs) that activate specific patterns of gene expression in the nucleus. The signaling system is conserved in the ...

In a recent study, researchers demonstrated that Z526, a novel dithiocarbamate-like compound, mitigates cancer-associated cachexia (CAC) both in vitro and in vivo.

Brain metastases are one of the most severe complications of melanoma, the most aggressive type of skin cancer. Researchers at the Institute for ...

In a new study, researchers have determined that a protein called NF-kB c-Rel can intensify the symptoms of psoriasis when activated by signals from the body's immune system. Understanding how 'c-Rel' ...

In cancer-associated cachexia, elevated TNF-α and IL-6 exacerbate muscle and fat loss by regulating multiple metabolic signaling pathways, which could be ameliorated by Z526's suppression of NF-κB ...