Unlike the role of RIP in recruitment of the IκB kinase (IKK)-complex to the TNFR, which leads to the activation of NF-κB, the kinase activity of RIP has death-promoting activity that is ...

IRAK1 further activates the E3 ubiquitin ligase-TRAF6 to synthesize the K63-linked polyubiquitin chains, leading to the recruitment and activation of the TAK1 complex. The activated TAK1 further ...

MAVS, in turn, activates signal pathways including NF-κB and IRF3 by stimulating downstream TBKI complex and IKK complex, thereby further activating IFN-α/β expression and inducing a natural antiviral ...

Bacterial and viral infections activate the signal transduction networks that regulate the innate immune system, and trigger the production of inflammatory mediators to combat these pathogens.

Future Virology. 2013;8(6):561-573. Apoptosis is an effective mechanism to destroy virus-infected cells. Central to this process is the interaction of FADD and procaspase-8. [58] During TNFR-1 ...

Feb. 7, 2025 — Researchers have analyzed the soft tissue from a fossilized plesiosaur for the first time. The results show that the long-necked marine reptile had both smooth and scaly skin ...

IκBα depletion does not affect NF-kB-dependent transcription, but causes a profound epigenetic rewiring in pluripotent stem cells, including alterations in H3K27me3, a histone mark catalyzed by ...

Non-alcoholic fatty liver disease (NAFLD) has rapidly become the most common chronic liver disease globally and is currently estimated to affect up to 38% of the global adult population. NAFLD is a ...

NF-κB is a well-known host transcription factor that exists in the form of the NF-κB-IκB complex in resting cells, but IκB can degrade and release the NF-κB dimer to enter the nucleus and promote gene ...