Bacterial and viral infections activate the signal transduction networks that regulate the innate immune system, and trigger the production of inflammatory mediators to combat these pathogens.

The IKK complex is made up of two similar catalytic components, IKKα (also named IKK1) and IKKβ (also referred to as IKK2), along with a regulatory subunit called IKKγ (also called NF-κB essential ...