Unlike the role of RIP in recruitment of the IκB kinase (IKK)-complex to the TNFR ... vanadate (2 mM), 10% glycerol and the protease inhibitor cocktail. Cytosolic fractions were precleared ...

Expert Rev Anticancer Ther. 2009;9(9):1305-1316. Very recently, the addition of bortezomib to chemotherapy was evaluated in DLBCL patients relapsing after R-CHOP. [49] To test the hypothesis that ...

2011;4(5):551-562. In addition, there are several trials currently examining the combination of bortezomib and histone deacetylase inhibitors (HDACi) or 5-azacitidine in the relapsed refractory T ...

The solid data in mouse embryonic stem cells include separation of function mutations in IκBα to dissect its non-canonical role as a chromatin regulator and its canonical function as NF-κB inhibitor.

Furthermore, IL-17 is essential in certain therapeutic contexts, such as treatments involving PI3K pathway inhibitors and Toll-like receptor agonists in Lewis lung carcinoma, where it can sustain the ...

Objectives The circadian clocks are internal timing mechanisms that drive ∼24-hour rhythms in a tissue-specific manner. Many aspects of the physiology of the intervertebral disc (IVD) show clear ...

Hepatic macrophages are a remarkably heterogeneous population consisting of self-renewing tissue-resident phagocytes, termed Kupffer cells (KCs), and recruited macrophages derived from peritoneal ...

Non-alcoholic fatty liver disease (NAFLD) has rapidly become the most common chronic liver disease globally and is currently estimated to affect up to 38% of the global adult population. NAFLD is a ...

In this useful study, the authors tested a novel approach to eradicate the HIV reservoir by constructing a herpes simplex virus (HSV)-based therapeutic vaccine designed to reactivate HIV from latently ...

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