Microglia reprogramming offers novel strategy to combat melanoma brain metastases
Brain metastases are one of the most severe complications of melanoma, the most aggressive type of skin cancer. Researchers ...
Armed robbery in Revesby5d
Novel Strategy Unveiled to Combat Melanoma Brain Mets
Brain metastases are one of the most severe complications of melanoma, the most aggressive type of skin cancer. Researchers at the Institute for ...
Deccan Chronicle8d
The Superpower of Cruciferous Veggies
We’ve all heard that eating vegetables is good for us, but what if certain veggies could do more than just keep us healthy?
Too Old to Operate9d
Bruton’s tyrosine kinase inhibition re-sensitizes multidrug-resistant DLBCL tumors driven by BCL10 gain-of-function mutants to venetoclax.
Disparate pathogenic mechanisms complicate precision-medicine efforts to treat diffuse large B-cell lymphoma (DLBCL), the most common lymphoma diagnosis. Though potentially curable with frontline ...
News Medical14d
New compound Z526 combats cancer-associated cachexia in preclinical models
In a recent study, researchers demonstrated that Z526, a novel dithiocarbamate-like compound, mitigates cancer-associated cachexia (CAC) both in vitro and in vivo.
EurekAlert!14d
Schematic illustration of Z526's effects on cancer-associated cachexia. (IMAGE)
In cancer-associated cachexia, elevated TNF-α and IL-6 exacerbate muscle and fat loss by regulating multiple metabolic signaling pathways, which could be ameliorated by Z526's suppression of NF-κB ...
GitHub19d
nf-kb
Add a description, image, and links to the nf-kb topic page so that developers can more easily learn about it.
Frontiers21d
Yunvjian decoction attenuates lipopolysaccharide-induced acute lung injury by inhibiting NF-κB/NLRP3 pathway and pyroptosis
Conclusion: YNJ attenuates LPS-induced ALI in mice by inhibiting pyroptosis of lung epithelial cells and macrophages via suppression of the NF-κB/NLRP3 pathway. Our findings provide novel insights ...
C&EN25d
Gut-Derived Ursodeoxycholic Acid from Saponins of Quinoa Regulated Colitis via Inhibiting the TLR4/NF-κB Pathway
National Grain Industry (Urban Grain and Oil Security) Technology Innovation Center, Shanghai 200093, China ...