Actuate Therapeutics, Inc. (NASDAQ: ACTU) (“Actuate” or the “Company”), a clinical-stage biopharmaceutical company focused on ...

In cancer-associated cachexia, elevated TNF-α and IL-6 exacerbate muscle and fat loss by regulating multiple metabolic signaling pathways, which could be ameliorated by Z526's suppression of NF-κB ...

Inflammatory pathways like the nuclear factor-kappa B (NF-κB), cyclooxygenase (COX), and mitogen-activated protein kinase (MAPK) pathways lead to the increased production of pro-inflammatory ...

Researchers discovered that gut microbiota-derived hexa-acylated LPS enhances the effectiveness of anti-PD-1 cancer ...

A research team led by Prof. WENG Jianping from the University of Science and Technology of China (USTC) of the Chinese Academy of Sciences (CAS) revealed that insulin-like growth factor-binding ...

Other TNF-related cytokines such as receptor activator of nuclear factor kappa B (RANK), its ligand, RANKL, and osteoprotegerin are important mediators in inflammatory processes in the gut and are ...

Antibodies were purchased from Enzo Biochem (New York, USA; RIP3), BD-Transduction Laboratories (Breda, Netherlands; RIP1), Santa Cruz Biotechnology (Dallas, USA; glyceraldehyde-3-phosphate ...

and inhibition of the activation of nuclear factor kappa B (NF-κB) and cJun N-terminal kinase (JNK), suggesting an important role for this protein in regulating endothelial functions.16 PTGS2, also ...

The manuscript addresses the 3D chromatin architecture in monocytes from patients with alcohol-associated hepatitis and its relationship to enhanced transcription of innate immune genes. While the ...

Background Aortic stenosis is a degenerative condition with high mortality in its severe stages and no preventive treatment.

Background The Prognostic Nutritional Index (PNI), calculated from serum albumin levels and lymphocyte counts, is a simple ...