Unlike the role of RIP in recruitment of the IκB kinase (IKK)-complex to the TNFR, which leads to the activation of NF-κB, the kinase activity of RIP has death-promoting activity that is ...

Activation of the canonical NF-κB pathway generally involves phosphorylation of the IKK kinase complex, which phosphorylates IκB kinase at serines 32 and 36, thereby enabling it to release RELA/p65 ...

In addition to establishing the DSTT research collaboration with the pharmaceutical industry I helped to establish a new company based in Dundee to commercialise the MRC PPU’s phosphorylation reagents ...

Hepatocyte growth factor-regulated tyrosine kinase substrate (HRS) is a subunit of ESCRT-0, and its UIM, which forms a short α-helix, binds two ubiquitin molecules with equal affinity.

One of the best studied signalling routes is the mitogen activated protein (MAP) kinase signal transduction pathway which plays a crucial role in many aspects of immune mediated inflammatory responses ...

This important study reveals a role for IκBα in the regulation of embryonic stem cell pluripotency. The solid data in mouse embryonic stem cells include separation of function mutations in IκBα to ...

Porcine cGAS, IFI16, IKK, IRF3 and p65 were cloned in either pcDNA-2HA or pEGFP-C1 and used as we described before (27). Human TBK1 (pcDNA-Myc-TBK1) and IKK (pcDNA-Myc-IKK) were cloned and preserved ...

When the viruses invade the body, they will be recognized by the host pattern recognition receptors (PRRs) such as Toll like receptor (TLR) or retinoic acid-induced gene-I like receptor (RLR), thus ...