“We have evidence that the signaling of hyperactive nuclear factor-kappa B(NF-kB), a family of proteins that acts like a switch to control which genes are turned on for inflammation, in the Krabbe ...

In a recent study, researchers demonstrated that Z526, a novel dithiocarbamate-like compound, mitigates cancer-associated cachexia (CAC) both in vitro and in vivo.

The final targets of TLRs are DNA-binding transcription factors (such as NF-kB and IRFs) that activate specific patterns of gene expression in the nucleus. The signaling system is conserved in the ...

Z526- a novel dithiocarbamate-like compound reverses cancer associated cachexia via mitigating NF-B signaling and oxidative ...

Dr. Ma adds, "Our results show that BB1 prevented the TNF-α increase in intestinal tight junction permeability via a toll-like receptor (TLR)-2 signal transduction pathway inhibition of NF-kB p50 ...

What makes the cells differ from one another is that different genes in that DNA are either turned on or off in each type of cell. Take a typical cell, such as a red blood cell. Each gene within ...

Disparate pathogenic mechanisms complicate precision-medicine efforts to treat diffuse large B-cell lymphoma (DLBCL), the most common lymphoma diagnosis. Though potentially curable with frontline ...

In cancer-associated cachexia, elevated TNF-α and IL-6 exacerbate muscle and fat loss by regulating multiple metabolic signaling pathways, which could be ameliorated by Z526's suppression of NF-κB ...

“We have evidence that the signaling of hyperactive nuclear factor-kappa B(NF-kB), a family of proteins that acts like a switch to control which genes are turned on for inflammation, in the Krabbe ...