This study reveals the key role of microglia, brain’s immune cells, in brain metastases progression and identifies a strategy ...

Brain metastases are one of the most severe complications of melanoma, the most aggressive type of skin cancer. Researchers at the Institute for ...

We’ve all heard that eating vegetables is good for us, but what if certain veggies could do more than just keep us healthy?

Disparate pathogenic mechanisms complicate precision-medicine efforts to treat diffuse large B-cell lymphoma (DLBCL), the most common lymphoma diagnosis. Though potentially curable with frontline ...

In a recent study, researchers demonstrated that Z526, a novel dithiocarbamate-like compound, mitigates cancer-associated cachexia (CAC) both in vitro and in vivo.

Actuate Therapeutics, Inc. (NASDAQ: ACTU) (“Actuate” or the “Company”), a clinical-stage biopharmaceutical company focused on ...

In cancer-associated cachexia, elevated TNF-α and IL-6 exacerbate muscle and fat loss by regulating multiple metabolic signaling pathways, which could be ameliorated by Z526's suppression of NF-κB ...

AQILION AB (publ) announces that the Company has resumed development of the its TAK1 program as the company has regained the control and ownership of the program. After reviewing and analysing the ...

Multiple signaling pathways, including Notch, JAK/STAT, NF-κb, and MAPK, regulate macrophage polarization ... interleukine-1β receptor; NFkB, nuclear factor-kB; JAK, Janus kinase; STAT, signal ...