Porcine cGAS, IFI16, IKK, IRF3 and p65 were cloned in either pcDNA-2HA or pEGFP-C1 and used as we described before (27). Human TBK1 (pcDNA-Myc-TBK1) and IKK (pcDNA-Myc-IKK) were cloned and preserved ...

Consequently, p65 degradation serves as an important regulatory mechanism ... MAVS, in turn, activates signal pathways including NF-κB and IRF3 by stimulating downstream TBKI complex and IKK complex, ...

This important study reveals a role for IκBα in the regulation of embryonic stem cell pluripotency. The solid data in mouse embryonic stem cells include separation of function mutations in IκBα to ...

In addition, HSV-ΔICP34.5 enhanced the phosphorylation of IKKα/β through the degradation of IκBα, leading to p65 accumulation in the nucleus to elicit NF-κB pathway-dependent reactivation of HIV ...

Objectives The circadian clocks are internal timing mechanisms that drive ∼24-hour rhythms in a tissue-specific manner. Many aspects of the physiology of the intervertebral disc (IVD) show clear ...

Objective Follistatin-like protein 1 (FSTL1) is widely recognised as a secreted glycoprotein, but its role in modulating macrophage-related inflammation during liver fibrosis has not been documented.