eLife16d
Purging viral latency by a bifunctional HSV-vectored therapeutic vaccine in chronically SIV-infected macaques
In addition, HSV-ΔICP34.5 enhanced the phosphorylation of IKKα/β through the degradation of IκBα, leading to p65 accumulation in the nucleus to elicit NF-κB pathway-dependent reactivation of HIV ...
Frontiers18d
5-deoxy-rutaecarpine protects against LPS-induced acute lung injury via inhibiting NLRP3 inflammasome-related inflammation
pcDNA3.1-IKKβ plasmid was purchased from Genscript Co., Ltd. (Nanjing, China). Antibodies against p-IκBα, IκBα, p-p65, and p65 were purchased from Bioworld Technology, Inc. (Nanjing, China); Antibody ...
eLife29d
Chromatin activity of IκBα mediates the exit from naïve pluripotency
This important study reveals a role for IκBα in the regulation of embryonic stem cell pluripotency. The solid data in mouse embryonic stem cells include separation of function mutations in IκBα to ...
Frontiers1mon
Decoding nature: multi-target anti-inflammatory mechanisms of natural products in the TLR4/NF-κB pathway
Within the NF-κB protein family, only p65, RelB, and c-Rel possess a transcriptional activation domain (TAD) that is accountable for triggering target genes. The IKK complex is made up of two similar ...