Unlike the role of RIP in recruitment of the IκB kinase (IKK)-complex to the TNFR, which leads to the activation of NF-κB, the kinase activity of RIP has death-promoting activity that is ...

In addition to establishing the DSTT research collaboration with the pharmaceutical industry I helped to establish a new company based in Dundee to commercialise the MRC PPU’s phosphorylation reagents ...

Hepatocyte growth factor-regulated tyrosine kinase substrate (HRS) is a subunit of ESCRT-0, and its UIM, which forms a short α-helix, binds two ubiquitin molecules with equal affinity.

The macrophage polarization-related pathways involving STAT3 include: Janus kinases (JAK)/STAT signaling pathway, NF-κB signaling pathway, phosphoinositide 3-kinase (PI3K)/protein kinase B (AKT) ...

One of the best studied signalling routes is the mitogen activated protein (MAP) kinase signal transduction pathway which plays a crucial role in many aspects of immune mediated inflammatory responses ...

This important study reveals a role for IκBα in the regulation of embryonic stem cell pluripotency. The solid data in mouse embryonic stem cells include separation of function mutations in IκBα to ...

Porcine cGAS, IFI16, IKK, IRF3 and p65 were cloned in either pcDNA-2HA or pEGFP-C1 and used as we described before (27). Human TBK1 (pcDNA-Myc-TBK1) and IKK (pcDNA-Myc-IKK) were cloned and preserved ...

Non-alcoholic fatty liver disease (NAFLD) has rapidly become the most common chronic liver disease globally and is currently estimated to affect up to 38% of the global adult population. NAFLD is a ...